Technological advancements are driving significant changes to human health and well-being. Innovation has transformed healthcare, ranging from practical digital solutions to treatments and therapies and impactful disruptions at a systems-level in the delivery of healthcare. What are the significant innovations which may shape our experience of human health and trajectories of population health and healthcare? What are the implications on the roles of patients, doctors and stakeholders in the healthcare system? Do we need a complete paradigm re-think of what the future of health and healthcare actually means?